Network-Based Identification of Biomarkers Coexpressed with Multiple Pathways

Network-Based Identification of Biomarkers Coexpressed with Multiple Pathways

Unraveling complex molecular interactions and networks and incorporating clinical information in modeling will present a paradigm shift in molecular medicine. Embedding biological relevance via modeling molecular networks and pathways has become increasingly important for biomarker identification in cancer susceptibility and metastasis studies. Here, we give a comprehensive overview of computat...

Differentially Coexpressed Disease Gene Identification Based on Gene Coexpression Network

Screening disease-related genes by analyzing gene expression data has become a popular theme. Traditional disease-related gene selection methods always focus on identifying differentially expressed gene between case samples and a control group. These traditional methods may not fully consider the changes of interactions between genes at different cell states and the dynamic processes of gene ex...

Identification of Multiple Input-multiple Output Non-linear System Cement Rotary Kiln using Stochastic Gradient-based Rough-neural Network

Because of the existing interactions among the variables of a multiple input-multiple output (MIMO) nonlinear system, its identification is a difficult task, particularly in the presence of uncertainties. Cement rotary kiln (CRK) is a MIMO nonlinear system in the cement factory with a complicated mechanism and uncertain disturbances. The identification of CRK is very important for different pur...

Identification of key genes and pathways involved in vitiligo vulgaris by gene network analysis

Background and Aim: Vitiligo vulgaris is an acquired, chronic skin and hair condition characterized clinically by loss of melanin, which, if untreated, is typically progressive and irreversible. The aim of the present study was to identify potential genes involved in the pathogenesis of vitiligo. Methods: One dataset of mRNA expression in patients with vitiligo (GSE65127) were obtained from ...

Bioinformatic identification of disease associated pathways by network based analysis